Imagine ifyour DNA could talk
Discover the best medications, genetic disease risks, and unique traits about your body — all from the DNA file you already have.
Discover what's
written in your DNA.
Your genetic file has 600,000 lines of data. OpenPGx extracts what matters and turns it into answers you understand.
Which medication works for you?
Discover how your body metabolizes Ozempic, antidepressants, anticoagulants, statins, and dozens more.
"CYP2D6 poor metabolizer — standard codeine dose may not work."
PharmGKB · CPIC · 500+Which diseases are you at higher risk for?
Alzheimer's, Parkinson's, breast cancer (BRCA), type 2 diabetes, cardiovascular, thrombosis, celiac, and more.
"APOE e3/e4 — 3.2x higher Alzheimer's risk."
GWAS · ClinVar · 18What does your DNA say about you?
Caffeine, lactose, chronotype, eye color, freckles, baldness, sun sneeze, pain sensitivity, and more.
"CYP1A2 AC — you metabolize caffeine slowly."
30+ traits · 10 categoriesWhich supplements does your body need?
MTHFR (folate), VDR (vitamin D), BCMO1 (vitamin A), FUT2 (B12), COMT, CBS.
"MTHFR TT — switch folic acid for methylfolate."
6 genes · personalized protocolOzempic, Wegovy, or Mounjaro?
GLP1R, GIPR, FTO, MC4R, CYP3A5 — how your DNA influences response and side effects.
"GIPR CG — semaglutide may work better than tirzepatide."
Nature 2026 · 27,885Why didn't that antidepressant work?
CYP2D6 and CYP2C19 determine how you metabolize SSRIs and SNRIs.
"CYP2C19 rapid metabolizer — escitalopram may have reduced effect."
CPIC Level AWhich is better for YOUR DNA?
Compare two medications side by side based on your genetic profile.
"For your CYP3A4, rosuvastatin is more predictable than atorvastatin."
Head-to-headWhat's your genetic potential?
VO2max, deep sleep, injury risk, pain sensitivity, omega-3, vitamin C.
"ACE II — your profile favors endurance."
12 markersThe curiosities everyone wants to know.
Eye color, freckles, sun sneeze, mosquito attraction, sweet/salty preference, misophonia.
"rs12913832 GG — high probability of blue eyes."
fun · shareableAsk your DNA anything.
AI uses your complete genetic profile as context for any question.
"Do I have a predisposition to gluten intolerance?"
no limits3 steps.
Your DNA answers.
1// claude_desktop_config.json2{3 "mcpServers": {4 "openpgx": {5 "command": "npx",6 "args": ["-y", "openpgx-mcp"]7 }8 }9}
We don't store
any of your data.
OpenPGx is an MCP plugin — a search tool. We only query public pharmacogenomics databases and return scientific data. Your DNA file is processed by the AI you use (Claude, GPT, etc.), on YOUR computer. OpenPGx never receives, stores, or has access to any personal or genetic data.
Search only — zero storage
The MCP only queries public databases (PharmGKB, CPIC). We never receive your DNA or personal data.
The AI processes, we don't
Your file is read by the AI (Claude, GPT) locally. OpenPGx is just the dictionary the AI looks up.
No account, no signup, no tracking
Install and use. We don't ask for email, login, or any personal information.
Open source — audit the code
100% open code on GitHub. Verify yourself that we collect nothing.
Based on science,
not guesswork.
OpenPGx queries the same databases used by researchers and geneticists. Every recommendation shows evidence levels and direct links to studies.
Everything your DNA
can tell you.
Works with the test
you already took.
Compatible with the world's leading genetic testing providers.
Haven't taken a test yet?
Our partners provide compatible raw data. Starting at $99 (US) or R$199 (BR).
See partners by countryInstall in 2 minutes.
Any AI.
Copy the config into your favorite MCP client. No app, no signup, no credit card.
100% local
Data never leaves your computer
Zero config
Copy, paste, works
Open source
MIT + Apache 2.0
Smart cache
Search → parse → cache
“I crossed my genome with my blood tests, microbiome, and supplements. I discovered things my doctor had never considered. So I thought: why not build the bridge? And why not make it open?”
Developer and entrepreneur passionate about bioinformatics and artificial intelligence. Created OpenPGx to democratize access to pharmacogenomics — connecting genetic data that millions of people already have with the science that can change how they care for their health.
Frequently asked questions
Yes. OpenPGx is just a search plugin (MCP) — we query public pharmacogenomics databases and return scientific data. We never receive, store, or access your DNA file or any personal data. Your genome is processed by the AI (Claude, GPT) locally on your computer. The code is open source — audit it yourself.
No. If you can copy and paste, you can install it. 2 minutes.
Yes. 23andMe, Genera, AncestryDNA, and any VCF file.
No. OpenPGx is an educational tool. Every recommendation includes evidence levels for you and your doctor to evaluate together.
Buy a kit online (23andMe in the US, Genera in Brazil). Spit in a tube, mail it back, and in 4-8 weeks you get your raw data by email.
Yes. DNA doesn't change. If you took 23andMe in 2018, the raw data still works.
No. Genetic risk is relative probability, not destiny. Lifestyle, environment, and other factors matter.
No. The MCP is 100% free and open source. It always will be.
No. OpenPGx is an MCP plugin — it works like a dictionary that the AI looks up. When you ask about a medication, the MCP searches public databases (PharmGKB, CPIC) and returns scientific data. Your DNA file is read and processed exclusively by the AI (Claude, GPT) on your computer. We never receive, see, or store any genetic or personal data.
Your DNA already knows.
Now you can too.
Free. Open source. Auditable. Improved by healthcare professionals and the community.